SPTA1 recombinant monoclonal antibody, clone SPTA1/2939R
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of K562 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human pancreas.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against partial human SPTA1.
Antibody Species
Rabbit
Immunogen
Recombinant protein corresponding to amino acids 356-475 of human SPTA1.
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG
Recommend Usage
ELISA (Use Ab at 2-4 ug/mL for coating)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1 mg/mL PBS
Storage Instruction
Store at -20 to -80°C.
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Applications
Western Blot (Cell lysate)
Western Blot (cell lysate) analysis of K562 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human pancreas.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPTA1
Entrez GeneID
6708Protein Accession#
P02549Gene Name
SPTA1
Gene Alias
EL2, SPTA
Gene Description
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Gene Ontology
HyperlinkGene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq
Other Designations
OTTHUMP00000021115|alpha-I spectrin|erythrocyte alpha-spectrin|erythroid alpha-spectrin|spectrin alpha chain, erythrocyte|spectrin, alpha, erythrocytic 1
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Interactome
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Disease
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