SPTA1 recombinant monoclonal antibody, clone R04-4Z1
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human SPTA1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against corresponding to human SPTA1.
Theoretical MW (kDa)
Calculated MW: 280 k
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG
Recommend Usage
Flow Cytometry (1/50-1/100)
Immunofluorescence (1/50-1/200)
Western Blot (1/500-1/1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — SPTA1
Entrez GeneID
6708Gene Name
SPTA1
Gene Alias
EL2, SPTA
Gene Description
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Gene Ontology
HyperlinkGene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq
Other Designations
OTTHUMP00000021115|alpha-I spectrin|erythrocyte alpha-spectrin|erythroid alpha-spectrin|spectrin alpha chain, erythrocyte|spectrin, alpha, erythrocytic 1
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