PTTG1 purified MaxPab mouse polyclonal antibody (B02P)
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More Files
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Western Blot (Transfected lysate)
Western Blot analysis of PTTG1 expression in transfected 293T cell line (H00009232-T04) by PTTG1 MaxPab polyclonal antibody.
Lane 1: PTTG1 transfected lysate(22.00 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PTTG1 on 293T cell. [antibody concentration 1 ug/ml]
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PTTG1 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PTTG1 protein.
Immunogen
PTTG1 (NP_004210.1, 1 a.a. ~ 202 a.a) full-length human protein.
Sequence
MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (71); Rat (71)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PTTG1 expression in transfected 293T cell line (H00009232-T04) by PTTG1 MaxPab polyclonal antibody.
Lane 1: PTTG1 transfected lysate(22.00 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PTTG1 on 293T cell. [antibody concentration 1 ug/ml]Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PTTG1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — PTTG1
Entrez GeneID
9232GeneBank Accession#
NM_004219.2Protein Accession#
NP_004210.1Gene Name
PTTG1
Gene Alias
EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
Gene Description
pituitary tumor-transforming 1
Omim ID
604147Gene Ontology
HyperlinkGene Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq
Other Designations
ESP1-associated protein 1|OTTHUMP00000160845|pituitary tumor-transforming protein 1|securin|tumor-transforming protein 1
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Interactome
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Pathway
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Disease
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