PTTG1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
PTTG1 transfected lysate.
Western Blot
Lane 1: PTTG1 transfected lysate ( 22.00 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PTTG1 full-length fragment
Host
Human
Theoretical MW (kDa)
22
Interspecies Antigen Sequence
Mouse (71); Rat (71)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PTTG1 antibody (H00009232-B02P) by Western Blots.
SDS-PAGE Gel
PTTG1 transfected lysate.
Western Blot
Lane 1: PTTG1 transfected lysate ( 22.00 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PTTG1
Entrez GeneID
9232GeneBank Accession#
NM_004219.2Protein Accession#
NP_004210.1Gene Name
PTTG1
Gene Alias
EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
Gene Description
pituitary tumor-transforming 1
Omim ID
604147Gene Ontology
HyperlinkGene Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq
Other Designations
ESP1-associated protein 1|OTTHUMP00000160845|pituitary tumor-transforming protein 1|securin|tumor-transforming protein 1
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Interactome
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Pathway
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Disease
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