PTTG1/PTTG2/PTTG3P polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate with PTTG1/PTTG2/PTTG3P polyclonal antibody (Cat # PAB24878).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human testis tissue using PTTG1/PTTG2/PTTG3P polyclonal antibody (Cat # PAB24878).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTTG1/PTTG2/PTTG3P.
Immunogen
A synthetic peptide corresponding to PTTG1/PTTG2/PTTG3P.
Host
Rabbit
Theoretical MW (kDa)
30
Reactivity
Human
Specificity
PTTG1/PTTG2/PTTG3P polyclonal antibody detects endogenous levels of PTTG1/PTTG2/PTTG3P protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1x PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate with PTTG1/PTTG2/PTTG3P polyclonal antibody (Cat # PAB24878).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human testis tissue using PTTG1/PTTG2/PTTG3P polyclonal antibody (Cat # PAB24878).Immunofluorescence
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Gene Info — PTTG1
Entrez GeneID
9232Gene Name
PTTG1
Gene Alias
EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
Gene Description
pituitary tumor-transforming 1
Omim ID
604147Gene Ontology
HyperlinkGene Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq
Other Designations
ESP1-associated protein 1|OTTHUMP00000160845|pituitary tumor-transforming protein 1|securin|tumor-transforming protein 1
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Gene Info — PTTG2
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Gene Info — PTTG3
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Interactome
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Pathway
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Disease
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