ADRB2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, using ADRB2 polyclonal antibody (Cat # PAB18066).
Peptide "+" means "with peptide blocking".
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRB2.
Immunogen
A synthetic peptide corresponding to residues surrounding S346 of human ADRB2.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to ADRB2.
Form
Liquid
Recommend Usage
Western Blot (1:500~1:1000)
Immunohistochemistry (1:50~1:100)
Immunofluorescence (1:500~1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, using ADRB2 polyclonal antibody (Cat # PAB18066).
Peptide "+" means "with peptide blocking".Immunohistochemistry
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRB2
Entrez GeneID
154Protein Accession#
P07550Gene Name
ADRB2
Gene Alias
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Gene Description
adrenergic, beta-2-, receptor, surface
Gene Ontology
HyperlinkGene Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq
Other Designations
beta-2 adrenergic receptor|beta-2 adrenoceptor|catecholamine receptor
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Modulation of postendocytic sorting of G protein-coupled receptors.
Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M.
Science 2002 Jul; 297(5581):615.
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Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.
S A Green, J Turki, M Innis, S B Liggett.
Biochemistry 1994 Aug; 33(32):9414.
Application：WB-Tr, Hamster, CHW cells.
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Primary structure of the human beta-adrenergic receptor gene.
Schofield PR, Rhee LM, Peralta EG.
Nucleic Acids Research 1987 Apr; 15(8):3636.
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Modulation of postendocytic sorting of G protein-coupled receptors.
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