Abnova's VHH Bispecific Ab Service offers custom-engineered bispecific antibodies incorporating an Fc domain, enhancing immune system engagement and extending in vivo half-life. These antibodies can simultaneously target two different antigens, making them powerful tools for applications such as cancer immunotherapy, targeted drug delivery, and autoimmune disease treatment. Unlike traditional bispecific formats, VHH bispecific antibodies have a fully hydrophilic surface, ensuring high solubility, stability, and minimal aggregation. This structure eliminates light-chain mispairing issues, ensuring precise targeting and efficient biological performance.

Workflow

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Advantages

  • Superior Stability
  • High Affinity and Specificity
  • Easy Conjugation
  • Prolonged Serum Half-Life
  • Activates immune effector functions like ADCC and CDC
  • Cost-Effectiveness and Scalable Production

 

 

Examples

Human PD-L1 x CD3e Bispecific VHH hIgG1

Flow cytometry

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