HGF (Human) ELISA Kit
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Specifications
Product Description
HGF (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human HGF.
Suitable Sample
Cell Culture Supernatant, Plasma (EDTA, Citrate), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
125 to 8000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — HGF
Entrez GeneID
3082Gene Name
HGF
Gene Alias
F-TCF, HGFB, HPTA, SF
Gene Description
hepatocyte growth factor (hepapoietin A; scatter factor)
Omim ID
142409Gene Ontology
HyperlinkGene Summary
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
fibroblast-derived tumor cytotoxic factor|hepatocyte growth factor|hepatopoietin A|lung fibroblast-derived mitogen|scatter factor
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Biochemical and Immunomorphological Evaluation of Hepatocyte Growth Factor and c-Met Pathway in Patients with Critical Limb Ischemia.
Vasuri F, Fittipaldi S, Abualhin M, Degiovanni A, Gargiulo M, Stella A, Pasquinelli G.
European Journal of Vascular and Endovascular Surgery 2014 Oct; 48(4):430.
Application：ELISA, Human, Serum.
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Localisation of hepatocyte growth factor and its receptor (c-met) protein and mRNA in human term placenta.
Kilby MD, Afford S, Li XF, Strain AJ, Ahmed A, Whittle MJ.
Growth Factors 1996 Jan; 13(1-2):133.
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Molecular cloning and expression of human hepatocyte growth factor.
Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K, Shimizu S.
Nature 1989 Nov; 342(6248):440.
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Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.
Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, et al..
Biochemical and Biophysical Research Communications 1989 Sep; 163(2):967.
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Biochemical and Immunomorphological Evaluation of Hepatocyte Growth Factor and c-Met Pathway in Patients with Critical Limb Ischemia.
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