CD99 recombinant monoclonal antibody, clone MIC2/1495R
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ewing's sarcoma with CD99 recombinant monoclonal antibody, clone MIC2/1495R (Cat # RAB00281).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CD99.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human MIC2.
Reactivity
Human
Specificity
Recognizes a sialoglycoprotein of 27-32kDa which identified as CD99.
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (2-4 ug/million cells)
Immunofluorescence (2-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ewing's sarcoma with CD99 recombinant monoclonal antibody, clone MIC2/1495R (Cat # RAB00281).Immunofluorescence
Flow Cytometry
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Gene Info — CD99
Entrez GeneID
4267Protein Accession#
P14209Gene Name
CD99
Gene Alias
MIC2, MIC2X, MIC2Y
Gene Description
CD99 molecule
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD99 antigen|E2 antigen|MIC2 (monoclonal antibody 12E7)|OTTHUMP00000022840|T-cell surface glycoprotein E2|antigen identified by monoclonal 12E7, Y homolog|antigen identified by monoclonal antibodies 12E7, F21 and O13|surface antigen MIC2
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Interactome
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Pathway
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Disease
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Publication Reference
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MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration.
Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M .
Cancer 1991 Apr; 67(7):1886.
Application：IHC-P, Human, Peripheral primitive neuroectodermal tumors, Sarcoma.
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MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration.
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