PIN1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIN1.
Immunogen
A synthetic peptide corresponding to N-terminus amino acids 134-150 of human PIN1 and mouse Pin1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:10000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PIN1
Entrez GeneID
5300Gene Name
PIN1
Gene Alias
DOD, UBL5
Gene Description
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Omim ID
601052Gene Ontology
HyperlinkGene Summary
The human PIN1 gene encodes an essential nuclear peptidylprolyl cis-trans isomerase (PPIase; EC 5.2.1.8) involved in regulation of mitosis. PIN1 belongs to a class of PPIases that includes the E. coli parvulin, yeast Ess1, and Drosophila dodo (dod) gene products (Lu et al., 1996 [PubMed 8606777]).[supplied by OMIM
Other Designations
peptidyl-prolyl cis/trans isomerase, NIMA-interacting|prolyl isomerase|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
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Gene Info — Pin1
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Interactome
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Disease
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Publication Reference
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Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP.
The Journal of Clinical Investigation 2008 May; 118(5):1877.
Application：IHC-P, WB, Human, Mouse, Mouse brain, coronal sections, SH-SY5Y cells.
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Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.
Barone MC, Desouza LA, Freeman RS.
Journal of Neurochemistry 2008 Jul; 106(2):734.
Application：IF, WB-Tr, Human, Mouse, HEK 293 cells, Mouse sympathetic neurons.
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Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity.
Pani E, Menigatti M, Schubert S, Hess D, Gerrits B, Klempnauer KH, Ferrari S.
Biochimica et Biophysica Acta 2008 Jun; 1783(6):1121.
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Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
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