MAML1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
MAML1 polyclonal antibody (Cat # PAB6471) (0.1 ug/mL) staining of human skeletal muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
MAML1 polyclonal antibody (Cat # PAB6471) (3.8 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MAML1.
Immunogen
A synthetic peptide corresponding to N terminus of human MAML1.
Sequence
VLPTCPMAEFALPR
Host
Goat
Theoretical MW (kDa)
108
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:128000)
Western blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5-3.8 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MAML1 polyclonal antibody (Cat # PAB6471) (0.1 ug/mL) staining of human skeletal muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
MAML1 polyclonal antibody (Cat # PAB6471) (3.8 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAML1
Entrez GeneID
9794Protein Accession#
NP_055572Gene Name
MAML1
Gene Alias
KIAA0200, Mam-1, Mam1
Gene Description
mastermind-like 1 (Drosophila)
Omim ID
605424Gene Ontology
HyperlinkGene Summary
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq
Other Designations
mastermind homolog|mastermind-like 1
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Interactome
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Pathway
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Disease
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Publication Reference
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MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD.
Nature Genetics 2000 Dec; 26(4):484.
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MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
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