DDB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
DDB1 polyclonal antibody (Cat # PAB6008). Western blot analysis of DDB1 expression in human placenta.
Western Blot (Cell lysate)
DDB1 polyclonal antibody (Cat # PAB6008). Western blot analysis of DDB1 expression in Jurkat.
Western Blot (Cell lysate)
DDB1 polyclonal antibody (Cat # PAB6008) staining (1 ug/mL) of NSO lysate (1E5 cells per lane). Detected by western blot using chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DDB1 polyclonal antibody (Cat # PAB6008). (4 ug/mL) staining of paraffin embedded Human Cortex. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DDB1.
Immunogen
A synthetic peptide corresponding to C-terminus of human DDB1.
Sequence
C-DLIKVVEELTRIH
Host
Goat
Theoretical MW (kDa)
127
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (4-6 ug/mL)
Western blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DDB1 polyclonal antibody (Cat # PAB6008). Western blot analysis of DDB1 expression in human placenta.Western Blot (Cell lysate)
DDB1 polyclonal antibody (Cat # PAB6008). Western blot analysis of DDB1 expression in Jurkat.Western Blot (Cell lysate)
DDB1 polyclonal antibody (Cat # PAB6008) staining (1 ug/mL) of NSO lysate (1E5 cells per lane). Detected by western blot using chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DDB1 polyclonal antibody (Cat # PAB6008). (4 ug/mL) staining of paraffin embedded Human Cortex. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DDB1
Entrez GeneID
1642Protein Accession#
NP_001914.3Gene Name
DDB1
Gene Alias
DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
Gene Description
damage-specific DNA binding protein 1, 127kDa
Omim ID
600045Gene Ontology
HyperlinkGene Summary
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq
Other Designations
DDB p127 subunit|damage-specific DNA binding protein 1|damage-specific DNA binding protein 1 (127kD)
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Interactome
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Pathway
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Publication Reference
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A genetic screen for candidate tumor suppressors identifies REST.
Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ.
Cell 2005 Jun; 121(6):837.
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A genetic screen for candidate tumor suppressors identifies REST.
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