PRKAA2 (phospho S175) polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PRKAA2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S175 of human PRKAA2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extract from A-431 cells, untreated or treated with EGF (200 ng/ml, 5 min), using PRKAA2 (phospho S175) polyclonal antibody (Cat # PAB5805).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRKAA2
Entrez GeneID
5563Gene Name
PRKAA2
Gene Alias
AMPK, AMPK2, PRKAA
Gene Description
protein kinase, AMP-activated, alpha 2 catalytic subunit
Omim ID
600497Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq
Other Designations
5'-AMP-activated protein kinase, catalytic alpha-2 chain|AMP-activated protein kinase alpha 2 catalytic subunit|AMPK-alpha-2 chain|OTTHUMP00000009993
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Interactome
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Pathway
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Disease
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Publication Reference
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Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase.
Beri RK, Marley AE, See CG, Sopwith WF, Aguan K, Carling D, Scott J, Carey F.
FEBS Letters 1994 Dec; 356(1):117.
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Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals.
Aguan K, Scott J, See CG, Sarkar NH.
Gene 1994 Nov; 149(2):345.
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Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase.
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