PRKAA2 recombinant monoclonal antibody, clone R06-2E8
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More Files
- More Functions
Western Blot
Western blot analysis of AMPK alpha 2 in C6, Hela lysates using human AMPK alpha 2 recombinant monoclonal antibody, clone R06-2E8 (Cat # RAB01608).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human AMPK alpha 2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human AMPK alpha 2
Theoretical MW (kDa)
Calculated MW: 62 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation(1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of AMPK alpha 2 in C6, Hela lysates using human AMPK alpha 2 recombinant monoclonal antibody, clone R06-2E8 (Cat # RAB01608).Immunoprecipitation
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Gene Info — PRKAA2
Entrez GeneID
5563Protein Accession#
P54646Gene Name
PRKAA2
Gene Alias
AMPK, AMPK2, PRKAA
Gene Description
protein kinase, AMP-activated, alpha 2 catalytic subunit
Omim ID
600497Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq
Other Designations
5'-AMP-activated protein kinase, catalytic alpha-2 chain|AMP-activated protein kinase alpha 2 catalytic subunit|AMPK-alpha-2 chain|OTTHUMP00000009993
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Interactome
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Disease
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