MAP3K7 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with MAP3K7 polyclonal antibody (Cat # PAB30783) shows strong cytoplasmic positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of A-431 cells with MAP3K7 polyclonal antibody (Cat # PAB30783) (Green) shows positivity in nucleus and cytoplasm.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human MAP3K7.
Immunogen
Recombinant protein corresponding to human MAP3K7.
Sequence
NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with MAP3K7 polyclonal antibody (Cat # PAB30783) shows strong cytoplasmic positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of A-431 cells with MAP3K7 polyclonal antibody (Cat # PAB30783) (Green) shows positivity in nucleus and cytoplasm. -
Gene Info — MAP3K7
Entrez GeneID
6885Protein Accession#
O43318Gene Name
MAP3K7
Gene Alias
TAK1, TGF1a
Gene Description
mitogen-activated protein kinase kinase kinase 7
Omim ID
602614Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000016870|OTTHUMP00000016871|OTTHUMP00000016872|OTTHUMP00000016873|TGF-beta activated kinase 1|transforming growth factor-beta-activated kinase 1
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Interactome
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Pathway
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Disease
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