MAP3K7 monoclonal antibody, clone ACHF-13
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate.
Immunofluorescence
Immunofluorescence analysis of A-431 cells.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human MAP3K7.
Immunogen
A synthetic peptide corresponding to human MAP3K7.
Host
Rabbit
Reactivity
Human
Specificity
The antibody reacts with human MAP3K7, in native form and recombinant. Superfamily members of MAP3K7 are not reactive to this antibody.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50)
Immunocytochemistry (1:100-1:500)
Immunofluorescence (1:100-1:500)
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate.Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Immunofluorescence analysis of A-431 cells.Flow Cytometry
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Gene Info — MAP3K7
Entrez GeneID
6885Protein Accession#
O43318Gene Name
MAP3K7
Gene Alias
TAK1, TGF1a
Gene Description
mitogen-activated protein kinase kinase kinase 7
Omim ID
602614Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000016870|OTTHUMP00000016871|OTTHUMP00000016872|OTTHUMP00000016873|TGF-beta activated kinase 1|transforming growth factor-beta-activated kinase 1
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Interactome
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Pathway
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Disease
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