MAP3K7 (phospho Ser439) recombinant monoclonal antibody, clone R07-7K2
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More Files
- More Functions
Western Blot
Western blot analysis of Lane1: 3T3, Lane2: C6 and Lane3: MCF-7 lysates with MAP3K7 (phospho Ser439) recombinant monoclonal antibody, clone R07-7K2 (Cat # RAB01877).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human MAP3K7.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic phosphopeptide corresponding to residues surrounding Ser439 of human MAP3K7.
Theoretical MW (kDa)
Calculated MW: 67 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
mmunofluorescence (1:50-1:200)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane1: 3T3, Lane2: C6 and Lane3: MCF-7 lysates with MAP3K7 (phospho Ser439) recombinant monoclonal antibody, clone R07-7K2 (Cat # RAB01877).Immunofluorescence
Immunoprecipitation
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Gene Info — MAP3K7
Entrez GeneID
6885Protein Accession#
O43318Gene Name
MAP3K7
Gene Alias
TAK1, TGF1a
Gene Description
mitogen-activated protein kinase kinase kinase 7
Omim ID
602614Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000016870|OTTHUMP00000016871|OTTHUMP00000016872|OTTHUMP00000016873|TGF-beta activated kinase 1|transforming growth factor-beta-activated kinase 1
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Interactome
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