Western blot analysis of Lane 1: UV treated RAW264.7 cells, Lane 2: antigen-specific peptide treated RAW264.7 cells with MAPKAPK2 (phospho S272) polyclonal antibody (Cat# PAB29630) at 1:500-1:1000 dilution.
Immunohistochemical staining of human brain tissue by MAPKAPK2 (phospho S272) polyclonal antibody (Cat# PAB29630) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq