NRAS polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NRAS.
Immunogen
A synthetic peptide corresponding to 15 amino acids at C-terminus of human NRAS.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
NRAS antibody is predicted to not cross-react with H-RAS
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NRAS in 293 cell lysate with NRAS polyclonal antibody (Cat # PAB27439) at (lane 1) 1 and (lane 2) 2 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NRAS
Entrez GeneID
4893Protein Accession#
NP_002515Gene Name
NRAS
Gene Alias
ALPS4, N-ras, NRAS1
Gene Description
neuroblastoma RAS viral (v-ras) oncogene homolog
Gene Ontology
HyperlinkGene Summary
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq
Other Designations
N-ras protein part 4|OTTHUMP00000013879|v-ras neuroblastoma RAS viral oncogene homolog
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Interactome
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Pathway
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Disease
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