MGST1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MGST1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human MGST1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MGST1 polyclonal antibody (Cat # PAB2597) in K-562 cell line lysates (35 ug/lane).MGST1 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — MGST1
Entrez GeneID
4257Protein Accession#
NP_665735;P10620Gene Name
MGST1
Gene Alias
GST12, MGC14525, MGST, MGST-I
Gene Description
microsomal glutathione S-transferase 1
Omim ID
138330Gene Ontology
HyperlinkGene Summary
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform. [provided by RefSeq
Other Designations
glutathione S-transferase 12
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Interactome
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Pathway
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Disease
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Publication Reference
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Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.
Prall WC, Czibere A, Jager M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M.
Mechanisms of Ageing and Development 2007 Jul; 128(9):503.
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Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population.
Zhang H, Liao LH, Liu SM, Lau KW, Lai AK, Zhang JH, Wang Q, Chen XQ, Wei W, Liu H, Cai JH, Lung ML, Tai SS, Wu M.
International Journal of Colorectal Disease 2007 Oct; 22(10):1185.
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Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.
Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA, Olson L, Kenealy SJ, Hauser M, Gilbert JR, Pericak-Vance MA.
Investigative Ophthalmology & Visual Science 2006 Jan; 47(1):329.
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Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.
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