SIPA1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SIPA1.
Immunogen
A synthetic peptide corresponding to 19 amino acids at N-terminus of human SIPA1.
Host
Rabbit
Reactivity
Human
Specificity
At least three isoforms of SIPA1 are known to exist; this antibody will recognize all three isoforms. This antibody is specific for SIPA1 and will not recognize the other SIPA1 family of proteins.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunofluorescence (20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SIPA1 in human brain tissue with SIPA1 polyclonal antibody (Cat # PAB25780) at 1 ug/mL.Immunofluorescence
Immunofluorescence analysis of SIPA1 in human brain with SIPA1 polyclonal antibody (Cat # PAB25780) at 20 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SIPA1
Entrez GeneID
6494Protein Accession#
AAH10492Gene Name
SIPA1
Gene Alias
MGC102688, MGC17037, SPA1
Gene Description
signal-induced proliferation-associated 1
Omim ID
602180Gene Ontology
HyperlinkGene Summary
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq
Other Designations
GTPase-activating protein Spa-1|p130 SPA-1|signal-induced proliferation-associated gene 1|signal-induced proliferation-associated protein 1
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