SIPA1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SIPA1.
Immunogen
A synthetic peptide corresponding to human SIPA1.
Sequence
C-ASKQLGSPTADLA
Host
Goat
Theoretical MW (kDa)
112
Reactivity
Human
Specificity
Both variants represent identical protein (NP_694985.28 and NP_006738.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
SIPA1 polyclonal antibody (Cat # PAB6576) staining (1 ug/mL) of human EBV-immortilized lymphoblastoid lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SIPA1
Entrez GeneID
6494Protein Accession#
NP_694985.28;NP_006738.2Gene Name
SIPA1
Gene Alias
MGC102688, MGC17037, SPA1
Gene Description
signal-induced proliferation-associated 1
Omim ID
602180Gene Ontology
HyperlinkGene Summary
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq
Other Designations
GTPase-activating protein Spa-1|p130 SPA-1|signal-induced proliferation-associated gene 1|signal-induced proliferation-associated protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression.
Hattori M, Tsukamoto N, Nur-e-Kamal MS, Rubinfeld B, Iwai K, Kubota H, Maruta H, Minato N.
Molecular and Cellular Biology 1995 Jan; 15(1):552.
Application:IF, IP, WB-Ce, Human, 70Z/3, β2M1, FDC-P2, LFD14, TGM78.3, P3U1 cells.
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Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression.
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