SPTLC1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPTLC1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SPTLC1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The SPTLC1 polyclonal antibody (Cat # PAB2501) is used in Western blot to detect SPTLC1 in 293 cell lysate. -
Gene Info — SPTLC1
Entrez GeneID
10558Protein Accession#
LCB1_HUMANGene Name
SPTLC1
Gene Alias
HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI
Gene Description
serine palmitoyltransferase, long chain base subunit 1
Gene Ontology
HyperlinkGene Summary
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000022810|OTTHUMP00000022811|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase subunit 1|serine-palmitoyl-CoA transferase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology.
Wei J, Yerokun T, Leipelt M, Haynes CA, Radhakrishna H, Momin A, Kelly S, Park H, Wang E, Carton JM, Uhlinger DJ, Merrill AH Jr.
Biochimica et Biophysica Acta 2009 Aug; 1791(8):746.
Application:WB-Ce, Human, HEK 293 cells.
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Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology.
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