SPTLC1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of SPTLC1 in human lung tissue lysate with SPTLC1 polyclonal antibody (Cat # PAB19392) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.
Immunohistochemistry
Immunohistochemical staining of human lung cells with SPTLC1 polyclonal antibody (Cat # PAB19392) at 5 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPTLC1.
Immunogen
A synthetic peptide corresponding to 17 amino acids near C-terminus of human SPTLC1.
Host
Rabbit
Reactivity
Human
Specificity
At least two isoforms of SPTLC1 are known to exist; this antibody will detect only isoform a. This antibody is predicted to not cross-react with SPT2.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SPTLC1 in human lung tissue lysate with SPTLC1 polyclonal antibody (Cat # PAB19392) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.Immunohistochemistry
Immunohistochemical staining of human lung cells with SPTLC1 polyclonal antibody (Cat # PAB19392) at 5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPTLC1
Entrez GeneID
10558Protein Accession#
NP_6406Gene Name
SPTLC1
Gene Alias
HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI
Gene Description
serine palmitoyltransferase, long chain base subunit 1
Gene Ontology
HyperlinkGene Summary
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000022810|OTTHUMP00000022811|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase subunit 1|serine-palmitoyl-CoA transferase 1
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Interactome
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Pathway
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Disease
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