Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with GPSM2 polyclonal antibody (Cat # PAB20374) at 1:250-1:500 dilution.
Immunohistochemical staining of human cerebellum with GPSM2 polyclonal antibody (Cat # PAB20374) shows strong cytoplasmic positivity in Purkinje cells in molecular layer and granular layer at 1:500-1:1000 dilution.
Immunofluorescent staining of human cell line U-251 MG with GPSM2 polyclonal antibody (Cat # PAB20374) at 1-4 ug/mL dilution shows positivity in cytoplasm.
Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002 [PubMed 11832491]).[supplied by OMIM
G-protein signalling modulator 2 (AGS3-like, C. elegans),LGN protein