TNNI1/TNNI2 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against native TNNI1/TNNI2.
Immunogen
Native purified TNNI1/TNNI2 from human skeletal muscle.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.5 (0.02% sodium azide, 50% glycerol (v/v))
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme Immunoassay
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Gene Info — TNNI1
Entrez GeneID
7135Gene Name
TNNI1
Gene Alias
DKFZp451O223, SSTNI, TNN1
Gene Description
troponin I type 1 (skeletal, slow)
Omim ID
191042Gene Ontology
HyperlinkGene Summary
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq
Other Designations
OTTHUMP00000033877|OTTHUMP00000033910|slow-twitch skeletal troponin I|troponin I, skeletal, slow
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Gene Info — TNNI2
Entrez GeneID
7136Gene Name
TNNI2
Gene Alias
AMCD2B, DA2B, FSSV
Gene Description
troponin I type 2 (skeletal, fast)
Gene Ontology
HyperlinkGene Summary
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000014141|OTTHUMP00000014142|troponin I fast twitch 2|troponin I, fast-twitch skeletal muscle isoform|troponin I, skeletal, fast
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