TNNI1 monoclonal antibody (M01), clone 4G6
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TNNI1 is approximately 1ng/ml as a capture antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant TNNI1.
Immunogen
TNNI1 (AAH12601, 1 a.a. ~ 187 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEGTEKERPVEVGDWRKNVEAMSGMEGRKKMFDAAKSPTSQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TNNI1 is approximately 1ng/ml as a capture antibody.ELISA
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Gene Info — TNNI1
Entrez GeneID
7135GeneBank Accession#
BC012601Protein Accession#
AAH12601Gene Name
TNNI1
Gene Alias
DKFZp451O223, SSTNI, TNN1
Gene Description
troponin I type 1 (skeletal, slow)
Omim ID
191042Gene Ontology
HyperlinkGene Summary
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq
Other Designations
OTTHUMP00000033877|OTTHUMP00000033910|slow-twitch skeletal troponin I|troponin I, skeletal, slow
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