TNNI1 monoclonal antibody, clone 7G2
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Specification
Product Description
Mouse monoclonal antibody raised against full length native TNNI1.
Immunogen
Native purified human TNNI1.
Host
Mouse
Reactivity
Human
Specificity
Troponin I from human skeletal muscle.Cross-reaction of this with cardiac troponin I is less then 1.5%.
Form
Liquid
Isotype
IgG2b
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNNI1
Entrez GeneID
7135Gene Name
TNNI1
Gene Alias
DKFZp451O223, SSTNI, TNN1
Gene Description
troponin I type 1 (skeletal, slow)
Omim ID
191042Gene Ontology
HyperlinkGene Summary
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq
Other Designations
OTTHUMP00000033877|OTTHUMP00000033910|slow-twitch skeletal troponin I|troponin I, skeletal, slow
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