Western blot analysis with ABCE1 polyclonal antibody (Cat # PAB18822) at 1 : 500 dilution. Lane 1 : 293 cell, no peptide blocked. Lane 2 : HeLa cell, no peptide blocked. Lane 3 : 293 cell, peptide blocked. Lane 4 : HeLa cell, peptide blocked.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
ATP-binding cassette, sub-family E, member 1,RNase L inhibitor,ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor