EGFR polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EGFR.
Immunogen
A synthetic peptide corresponding to residues surrounding S1070 of human EGFR.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to EGFR.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of the extracts from SK-OV-3 cells untreated or treated with EGF using EGFR polyclonal antibody (Cat # PAB18467).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin- embedded human breast carcinoma, using EGFR polyclonal antibody (Cat # PAB18467).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — EGFR
Entrez GeneID
1956Protein Accession#
P00533Gene Name
EGFR
Gene Alias
ERBB, ERBB1, HER1, PIG61, mENA
Gene Description
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
Other Designations
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|epidermal growth factor receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes.
Huang ST, Cidlowski JA.
FASEB Journal 2002 Jun; 16(8):825.
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Novel role for JNK as a stress-activated Bcl2 kinase.
Deng X, Xiao L, Lang W, Gao F, Ruvolo P, May WS Jr.
The Journal of Biological Chemistry 2001 Jun; 276(26):23681.
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Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes.
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