Western blot analysis of TNFRSF21 in K-562 (1, 3) and Raji (2, 4) whole cell lysate in the absence (1, 2) or presence (3, 4) of blocking peptide with TNFRSF21 polyclonal antibody (Cat # PAB12839) at 1 : 500 dilution.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq
OTTHUMP00000016561,OTTHUMP00000039915,TNFR-related death receptor 6,death receptor 6