HSPA5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HSPA5 on HeLa whole cell extracts using HSPA5 polyclonal antibody (Cat # PAB12413).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HSPA5.
Immunogen
A synthetic peptide corresponding to amino acids 250-300 of human HSPA5.
Host
Rabbit
Reactivity
Bovine, Chicken, Fruit fly, Human, Mouse, Nematoda, Primates, Rat, Sheep, Zebra fish
Form
Liquid
Purification
Immunogen affinity purification
Recommend Usage
Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HSPA5 on HeLa whole cell extracts using HSPA5 polyclonal antibody (Cat # PAB12413). -
Gene Info — HSPA5
Entrez GeneID
3309Protein Accession#
P11021Gene Name
HSPA5
Gene Alias
BIP, FLJ26106, GRP78, MIF2
Gene Description
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Omim ID
138120Gene Ontology
HyperlinkGene Summary
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM
Other Designations
Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD)|OTTHUMP00000022124|heat shock 70kD protein 5 (glucose-regulated protein, 78kD)|heat shock 70kDa protein 5
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Interactome
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Pathway
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Disease
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Publication Reference
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Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.
Chiu CC, Lin CY, Lee LY, Chen YJ, Kuo TF, Chang JT, Liao CT, Wang HM, Yen TC, Shen CR, Liao SK, Cheng AJ.
Molecular Cancer Therapeutics 2008 Sep; 7(9):2788.
Application：IF, IHC-P, WB, Human, Head and neck cancer, normal keratinocytes, BM1, BM2, 076, Fadu, Detroit, OECM1 cells, Mouse xenograft tumors.
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Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.
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