HSPA5 recombinant monoclonal antibody, clone R03-5B3
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More Files
- More Functions
Western Blot
Western blot analysis of GRP78 BiP in C6 lysates using GRP78 BiP antibody.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human HSPA5.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human GRP78 BiP.
Theoretical MW (kDa)
Calculated MW: 72 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of GRP78 BiP in C6 lysates using GRP78 BiP antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — HSPA5
Entrez GeneID
3309Protein Accession#
P11021Gene Name
HSPA5
Gene Alias
BIP, FLJ26106, GRP78, MIF2
Gene Description
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Omim ID
138120Gene Ontology
HyperlinkGene Summary
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM
Other Designations
Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD)|OTTHUMP00000022124|heat shock 70kD protein 5 (glucose-regulated protein, 78kD)|heat shock 70kDa protein 5
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Interactome
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Pathway
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Disease
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