LRRK2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LRRK2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 2480-2527 of human LRRK2.
Host
Rabbit
Reactivity
Human, Mouse, Pig, Primates, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In Tris-glycine (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LRRK2 in increasing amounts of human lymphoblast using LRRK2 polyclonal antibody (Cat # PAB12393).Immunohistochemistry (Frozen sections)
Immunohistochemistry
Staining of LRRK2 in mouse brainstem using LRRK2 polyclonal antibody (Cat # PAB12393). -
Gene Info — LRRK2
Entrez GeneID
120892Protein Accession#
Q5S007Gene Name
LRRK2
Gene Alias
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Description
leucine-rich repeat kinase 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq
Other Designations
Parkinson disease (autosomal dominant) 8|augmented in rheumatoid arthritis 17
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Interactome
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Disease
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Publication Reference
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ.
Neuroscience 2007 Jul; 147(4):1047.
Application:IF, IHC-P, WB, Human, Mouse, Brain from Human and Mouse.
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
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