LRRK2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of LRRK2 in 50 ug of crude bovine brain membrane using LRRK2 polyclonal antibody (Cat # PAB12394).
Western Blot (Cell lysate)
Western blot analysis of LRRK2 in HeLa whole cell lysate (RIPA) using LRRK2 polyclonal antibody (Cat # PAB12394) at 1 : 5,000 dilution.
Immunofluorescence
Immunofluorescent CAD cells transfected with human wild-type LRRK2 (1 : 2000) using LRRK2 polyclonal antibody (Cat # PAB12394).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LRRK2.
Immunogen
A synthetic peptide corresponding to amino acids 2500-2527 of human LRRK2.
Host
Rabbit
Reactivity
Bovine, Human, Mouse
Specificity
This antibody reacts with LRRK2.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of LRRK2 in 50 ug of crude bovine brain membrane using LRRK2 polyclonal antibody (Cat # PAB12394).Western Blot (Cell lysate)
Western blot analysis of LRRK2 in HeLa whole cell lysate (RIPA) using LRRK2 polyclonal antibody (Cat # PAB12394) at 1 : 5,000 dilution.Immunohistochemistry
Immunofluorescence
Immunofluorescent CAD cells transfected with human wild-type LRRK2 (1 : 2000) using LRRK2 polyclonal antibody (Cat # PAB12394). -
Gene Info — LRRK2
Entrez GeneID
120892Protein Accession#
Q5S007Gene Name
LRRK2
Gene Alias
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Description
leucine-rich repeat kinase 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq
Other Designations
Parkinson disease (autosomal dominant) 8|augmented in rheumatoid arthritis 17
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Interactome
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Disease
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Publication Reference
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ.
Neuroscience 2007 Jul; 147(4):1047.
Application：IF, IHC-P, WB, Human, Mouse, Brain from Human and Mouse.
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LRRK2 expression in normal and pathologic human brain and in human cell lines.
Miklossy J, Arai T, Guo JP, Klegeris A, Yu S, McGeer EG, McGeer PL.
Journal of Neuropathology and Experimental Neurology 2006 Oct; 65(10):953.
Application：IF, IHC, WB, Human, Human brains.
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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.
Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, van der Brug M, Lopez de Munain A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de Silva R, Lees A, Marti-Masso JF, Perez-Tur J, Wood NW, Singleton AB.
Neuron 2004 Nov; 44(4):595.
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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T.
Neuron 2004 Nov; 44(4):601.
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
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