SH2D1A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant SH2D1A.
Immunogen
Recombinant protein corresponding to full length SH2D1A.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using SH2D1A polyclonal antibody (Cat # PAB10367) on NK-92 cell lysate at 10 ug/mL).Immunoprecipitation
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Gene Info — SH2D1A
Entrez GeneID
4068Gene Name
SH2D1A
Gene Alias
DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD
Gene Description
SH2 domain protein 1A
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Duncan's disease|OTTHUMP00000023976|SLAM-associated protein|T cell signal transduction molecule SAP|signaling lymphocyte activation molecule-associated protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Latour S, Gish G, Helgason CD, Humphries RK, Pawson T, Veillette A.
Nature Immunology 2001 Aug; 49(4):189.
Application:WB, Mouse, BI-141 cells, Mouse thymocytes.
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Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP.
Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL.
PNAS 2001 Jun; 98(13):7449.
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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.
Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C.
Nature 1998 Oct; 395(6701):462.
Application:IP, WB-Ce, WB-Tr, Human, Monkey, Jurkat, COS-7 cells, Peripheral blood lymphocytes.
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Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
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