Western blot analysis of lysates of McA-RH7777 cells transfected with full length human S1PR1 protein using S1PR1 polyclonal antibody (Cat # PAB10360) at 10 ug/mL (Lane 1), antibody preincubated with specific blocking peptide (Lane 2) and antibody preincubated with non-specific control peptide (Lane 3).
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq