Immunoblotting of DCLRE1C polyclonal antibody (Cat # PAB10023) was used at a 1 : 500 dilution to detect DCLRE1C is various cell lysates by Western blot. CJ is an DCLRE1C deficient cell lineand so no band is visible. This antibody detects a band of approximately 90 KDa (predicted molecular weight: 78 KDa).
Immunohistochemistry of DCLRE1C polyclonal antibody (Cat # PAB10023) was used at a 1 : 1000 dilution to detect DCLRE1C by immunohistochemistry in human spleen. Positive staining of T cells and B lymphocytes is observed in thymus, lymph nodes and spleen. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Alan Yen, Life Span Biosciences, Seattle, WA.
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq
OTTHUMP00000019166,OTTHUMP00000019167,OTTHUMP00000019168,OTTHUMP00000019170,OTTHUMP00000019171,OTTHUMP00000019172,OTTHUMP00000019174,OTTHUMP00000045150,artemis protein,severe combined immunodeficiency, type a (Athabascan)