DCLRE1C (phospho S645) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of DCLRE1C.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S645 of human DCLRE1C.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — DCLRE1C
Entrez GeneID
64421Gene Name
DCLRE1C
Gene Alias
A-SCID, DCLREC1C, FLJ11360, FLJ36438, RS-SCID, SCIDA, SNM1C
Gene Description
DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq
Other Designations
OTTHUMP00000019166|OTTHUMP00000019167|OTTHUMP00000019168|OTTHUMP00000019170|OTTHUMP00000019171|OTTHUMP00000019172|OTTHUMP00000019174|OTTHUMP00000045150|artemis protein|severe combined immunodeficiency, type a (Athabascan)
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphorylation of Artemis following irradiation-induced DNA damage.
Poinsignon C, de Chasseval R, Soubeyrand S, Moshous D, Fischer A, Hache RJ, de Villartay JP.
European Journal of Immunology 2004 Nov; 34(11):3146.
Application：WB, Human, AT1BR, HEK 293T cells.
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The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination.
Poinsignon C, Moshous D, Callebaut I, de Chasseval R, Villey I, de Villartay JP.
The Journal of Experimental Medicine 2004 Feb; 199(3):315.
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Phosphorylation of Artemis following irradiation-induced DNA damage.
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