SYK (phospho Y525/Y526) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of SYK.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y525/Y526 of human SYK.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SYK (phospho Y525/526) polyclonal antibody (Cat # PAB0623) in mouse liver tissue lysate (35 ug/lane). Phospho-SYK (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with SYK (phospho Y525/526) polyclonal antibody (Cat # PAB0623) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — SYK
Entrez GeneID
6850Protein Accession#
NP_003168;P43405Gene Name
SYK
Gene Alias
DKFZp313N1010, FLJ25043, FLJ37489
Gene Description
spleen tyrosine kinase
Omim ID
600085Gene Ontology
HyperlinkOther Designations
OTTHUMP00000021627|OTTHUMP00000021628
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Interactome
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Pathway
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Disease
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Publication Reference
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Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma.
Wang S, Ding YB, Chen GY, Xia JG, Wu ZY.
World Journal of Gastroenterology 2004 Jun; 10(12):1815.
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An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade.
Hayes MJ, Cambridge G.
Molecular Immunology 2004 Jun; 41(4):457.
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T-cell receptor-induced phosphorylation of the zeta chain is efficiently promoted by ZAP-70 but not Syk.
Steinberg M, Adjali O, Swainson L, Merida P, Di Bartolo V, Pelletier L, Taylor N, Noraz N.
Blood 2004 Aug; 104(3):760.
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Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma.
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