ZAP70/SYK recombinant monoclonal antibody, clone Zap70Y319-A3
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of L929 cells secondary antibody only (blue) or 0.1 ug/mL of isotype control (orange) or of Phospho-Zap70 (Tyr319)/Syk (Tyr352) antibody ZapY319-A3 (green).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ZAP70 | SYK.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of L929 cells secondary antibody only (blue) or 0.1 ug/mL of isotype control (orange) or of Phospho-Zap70 (Tyr319)/Syk (Tyr352) antibody ZapY319-A3 (green). -
Gene Info — SYK
Entrez GeneID
6850Protein Accession#
P43403 | P43405Gene Name
SYK
Gene Alias
DKFZp313N1010, FLJ25043, FLJ37489
Gene Description
spleen tyrosine kinase
Omim ID
600085Gene Ontology
HyperlinkOther Designations
OTTHUMP00000021627|OTTHUMP00000021628
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Gene Info — ZAP70
Entrez GeneID
7535Protein Accession#
P43403 | P43405Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Pathway
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Disease
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