ZAP70/SYK recombinant monoclonal antibody, clone Zap70Y319-A3 (PE)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Jurkat cells unstained untreated cells as negative control (blue) or stained and untreated (red) or stained and treated with pervanadate (green) using phospho-Zap70 (Tyr319)/Syk (Tyr352) antibody ZapY319-A3 PE conjugate.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ZAP70/SYK.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.
Reactivity
Human
Form
Liquid
Conjugation
PE
Purification
Protein A purification, Protein G purification
Isotype
IgG
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Jurkat cells unstained untreated cells as negative control (blue) or stained and untreated (red) or stained and treated with pervanadate (green) using phospho-Zap70 (Tyr319)/Syk (Tyr352) antibody ZapY319-A3 PE conjugate. -
Gene Info — SYK
Entrez GeneID
6850Protein Accession#
P43403;P43405Gene Name
SYK
Gene Alias
DKFZp313N1010, FLJ25043, FLJ37489
Gene Description
spleen tyrosine kinase
Omim ID
600085Gene Ontology
HyperlinkOther Designations
OTTHUMP00000021627|OTTHUMP00000021628
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Gene Info — ZAP70
Entrez GeneID
7535Protein Accession#
P43403;P43405Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Pathway
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Disease
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