Human ductal breast epithelial tumor, T-47D cells.
Theoretical MW (kDa):
The mouse monoclonal antibody 67A4 recognizes CDH1 (CD324), an approximately 100 kDa epithelial cell adhesion molecule, whose detection is important for determination of invasive potential of epithelial neoplasms.
Size-exclusion chromatography purification
Flow Cytometry (10 uL reagent/100 uL of whole blood or 106 cells) The optimal working dilution should be determined by the end user.
In PBS, pH 7.4 (0.02% BSA, 0.09% sodium azide)
Store in the dark at 4°C. Avoid prolonged exposure to light. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq