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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry (Frozen sections)

Immunofluorescence

Immunoprecipitation

Entrez GeneID

Protein Accession#

Gene Name

CDH1

Gene Alias

Arc-1, CD324, CDHE, ECAD, LCAM, UVO

Gene Description

cadherin 1, type 1, E-cadherin (epithelial)

Omim ID

Gene Ontology

Gene Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq

Other Designations

cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin

Entrez GeneID

Protein Accession#

Gene Name

CDH2

Gene Alias

CD325, CDHN, CDw325, NCAD

Gene Description

cadherin 2, type 1, N-cadherin (neuronal)

Omim ID

Gene Ontology

Gene Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq

Other Designations

N-cadherin 1|cadherin 2, N-cadherin (neuronal)|cadherin 2, type 1|calcium-dependent adhesion protein, neuronal|neural cadherin

Entrez GeneID

Protein Accession#

Gene Name

CDH3

Gene Alias

CDHP, HJMD, PCAD

Gene Description

cadherin 3, type 1, P-cadherin (placental)

Omim ID

Gene Ontology

Gene Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq

Other Designations

cadherin 3, type 1|calcium-dependent adhesion protein, placental