CDH1 recombinant monoclonal antibody, clone 30B12
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: Mouse Liver tissue lysate.
Immunohistochemistry
Immunohistochemistry image of CDH1 recombinant monoclonal antibody, clone 30B12 diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system.
Flow Cytometry
Immunofluorescence staining of MCF-7 Cells with CDH1 recombinant monoclonal antibody, clone 30B12 at 1:100, counter-stained with DAPI.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human and mouse CDH1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human CDH1.
Theoretical MW (kDa)
Calculated MW: 80-13
Reactivity
Human, Mouse
Form
Liquid
Purification
Affinity chromatography purification
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry(1:50-1:200)
Western Blot(1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 0.02% sodium azide and 50% glycerol)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Mouse Liver tissue lysate.Immunohistochemistry
Immunohistochemistry image of CDH1 recombinant monoclonal antibody, clone 30B12 diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Immunofluorescence staining of MCF-7 Cells with CDH1 recombinant monoclonal antibody, clone 30B12 at 1:100, counter-stained with DAPI. -
Gene Info — CDH1
Entrez GeneID
999Protein Accession#
P12830Gene Name
CDH1
Gene Alias
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Gene Description
cadherin 1, type 1, E-cadherin (epithelial)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
Other Designations
cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin
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Interactome
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Pathway
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Disease
- Adenocarcinoma
- Asthma
- Breast cancer
- Breast Neoplasms
- Bronchiolitis
- Carcinoma
- Cleft Lip
- Cleft Palate
- Colitis
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