VCAM1 monoclonal antibody, clone STA
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Specification
Product Description
Mouse monoclonal antibody raised against native VCAM1.
Immunogen
Native purified VCAM1 from human DS6 T cell line.
Host
Mouse
Theoretical MW (kDa)
100-110
Reactivity
Human
Specificity
This antibody STA recognizes VCAM1 antigen (CD106), a 100-110 KDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyteadhesion, and a costimulation molecule.
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA
Flow Cytometry (4-6 ug/mL)
Immunohistochemistry
Immunoprecipitation
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — VCAM1
Entrez GeneID
7412Gene Name
VCAM1
Gene Alias
CD106, DKFZp779G2333, INCAM-100, MGC99561
Gene Description
vascular cell adhesion molecule 1
Omim ID
192225Gene Ontology
HyperlinkGene Summary
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
CD106 antigen|OTTHUMP00000012650|OTTHUMP00000012651
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Interactome
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Pathway
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Disease
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Publication Reference
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Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes.
Paessens LC, Singh SK, Fernandes RJ, van Kooyk Y.
Molecular Immunology 2008 Jan; 45(1):42.
Application:IF, IHC-Fr, Mouse, Mouse thymic cortex.
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Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro.
Yen YT, Liao F, Hsiao CH, Kao CL, Chen YC, Wu-Hsieh BA.
Journal of Virology 2006 Mar; 80(6):2684.
Application:IF, Human, A-549-SARS-CoV cells.
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Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform.
Leca G, Mansur SE, Bensussan A.
Journal of Immunology 1995 Feb; 154(3):1069.
Application:ELISA, Flow Cyt, IP, Human, Human T cells.
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Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes.
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