HSP90AA1/HSP90AA2 monoclonal antibody, clone Hyb-K41009
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Specifications
Product Description
Mouse monoclonal antibody raised against recombinant HSP90AA1/HSP90AA2.
Immunogen
Recombinant protein corresponding to human HSP90AA1/HSP90AA2.
Host
Mouse
Reactivity
Human
Specificity
Detects 90KDa proteins corresponding to the molecular mass of Hsp90alpha. Identical to human (Alpha Specific).
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunohistochemical staining of mouse colon cancer with HSP90AA1/HSP90AA2 monoclonal antibody, clone Hyb-K41009 (Cat # MAB6619). In 5,000 fold Amplify.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSP90AA1
Entrez GeneID
3320Gene Name
HSP90AA1
Gene Alias
FLJ31884, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2
Gene Description
heat shock protein 90kDa alpha (cytosolic), class A member 1
Omim ID
140571Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM
Other Designations
heat shock 90kD protein 1, alpha|heat shock 90kD protein 1, alpha-like 4|heat shock 90kD protein, alpha-like 4|heat shock 90kDa protein 1, alpha
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Gene Info — HSP90AA2
Entrez GeneID
3324Gene Name
HSP90AA2
Gene Alias
HSP90ALPHA, HSPCA, HSPCAL3
Gene Description
heat shock protein 90kDa alpha (cytosolic), class A member 2
Omim ID
140575Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM
Other Designations
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
Neckers L.
Trends in Molecular Medicine 2002 Apr; 8(4 Suppl):S55.
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Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.
Loo MA, Jensen TJ, Cui L, Hou Y, Chang XB, Riordan JR.
The EMBO Journal 1998 Dec; 17(23):6879.
Application:IP, WB-Ce, Mouse, BHK cells.
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Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes.
Barent RL, Nair SC, Carr DC, Ruan Y, Rimerman RA, Fulton J, Zhang Y, Smith DF.
Molecular Endocrinology 1998 Mar; 12(3):342.
Application:WB, Recombinant protein.
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
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