ITGAV monoclonal antibody, clone 13C2
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGAV.
Immunogen
Native purified from human osteoclastoma tissue.
Host
Mouse
Reactivity
Human
Specificity
human CD51.
Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (1 ug/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
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Gene Info — ITGAV
Entrez GeneID
3685Gene Name
ITGAV
Gene Alias
CD51, DKFZp686A08142, MSK8, VNRA
Gene Description
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Omim ID
193210Gene Ontology
HyperlinkGene Summary
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
Integrin, alpha-V (vitronectin receptor, alpha polypeptide)|antigen identified by monoclonal antibody L230|integrin alpha-V
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Interactome
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Pathway
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Disease
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Publication Reference
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Adaptation to replating of dendritic cells synergizes with Toll-like receptor stimuli and enhances the pro-inflammatory cytokine profile.
Kolanowski ST, van Schijndel GM, van Ham SM, Ten Brinke A.
Cytotherapy 2016 Jul; 18(7):902.
Application:Incubated, Recombinant protein.
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Platelet integrins.
Ginsberg MH, Xiaoping D, O'Toole TE, Loftus JC, Plow EF.
Thromb Haemost 1993 Jul; 70(1):87.
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Platelet membrane glycoproteins: functions in cellular interactions.
Kieffer N, Phillips DR.
Annual Review of Cell Biology 1990 Nov; 6:329.
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Adaptation to replating of dendritic cells synergizes with Toll-like receptor stimuli and enhances the pro-inflammatory cytokine profile.
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