Products

Western Blot (Cell lysate)

Western blot analysis of U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate with ITGAV recombinant monoclonal antibody, clone 5G3 (Cat # RAB07452).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human placenta tissue using ITGAV recombinant monoclonal antibody, clone 5G3 (Cat # RAB07452) on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

3685

Protein Accession#

P06756

Gene Name

ITGAV

Gene Alias

CD51, DKFZp686A08142, MSK8, VNRA

Gene Description

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Omim ID

193210

Gene Ontology

Hyperlink

Gene Summary

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq

Other Designations

Integrin, alpha-V (vitronectin receptor, alpha polypeptide)|antigen identified by monoclonal antibody L230|integrin alpha-V