CD55 monoclonal antibody, clone MEM-118 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD55.
Immunogen
Native purified CD55 from HPB-ALL human T cell line.
Host
Mouse
Theoretical MW (kDa)
60-70
Reactivity
Human, Non-Human Primates
Specificity
This antibody recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 KDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.
Form
Liquid
Conjugation
FITC
Isotype
IgM
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD55
Entrez GeneID
1604Gene Name
CD55
Gene Alias
CR, CROM, DAF, TC
Gene Description
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Omim ID
125240Gene Ontology
HyperlinkGene Summary
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CD55 antigen|decay accelerating factor for complement
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Interactome
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Pathway
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Disease
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Publication Reference
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Neurosteroids reduce inflammation after TBI through CD55 induction.
VanLandingham JW, Cekic M, Cutler S, Hoffman SW, Stein DG.
Neuroscience Letters 2007 Sep; 425(2):94.
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Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.
Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM.
The Journal of Biological Chemistry 2007 Jul; 282(30):22023.
Application：Flow Cyt, Func, Human, PBMCs.
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Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms.
Miwa T, Maldonado MA, Zhou L, Yamada K, Gilkeson GS, Eisenberg RA, Song WC.
The American Journal of Pathology 2007 Apr; 170(4):1258.
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Neurosteroids reduce inflammation after TBI through CD55 induction.
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